Essentially, you cannot just run the DESCENT2.EXE file. You need a translation layer. Before you pick a method, you need the game data. Whether you own the original CDs or have purchased the game from a digital distributor like Steam or GOG.com, the core files are the same.
Most digital releases (Steam/GOG) come with a pre-configured version of DOSBox. If you are installing from a CD, you must install DOSBox manually.
Windows 10, conversely, is an NT-based architecture that abstracts hardware away from software for security and stability. Windows 10 doesn’t know how to talk to the old DOS drivers, and the old DOS drivers certainly don’t know how to talk to modern NVIDIA or AMD graphics cards.
Here are the two top contenders for Windows 10. DXX-Rebirth is arguably the most faithful source port for Descent II . It retains the look and feel of the original game but adds quality-of-life features.